Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen

J Infect Dis. 2006 May 15;193(10):1459-63. doi: 10.1086/503370. Epub 2006 Apr 12.


In this report, we show that the Chlamydia trachomatis-specific CD8+ T cell antigen class I accessible protein-1 (Cap1) is expressed during the early stages of the C. trachomatis developmental cycle. We provide additional evidence suggesting that Cap1 may be important in early immune recognition of the organism. Understanding the temporal and spatial expression of CD8+ T cell antigens such as Cap1 may be beneficial in designing multisubunit vaccines to stimulate a vigorous immune response against C. trachomatis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antigens, Bacterial / immunology*
  • Bacterial Vaccines / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • Cell Line
  • Chlamydia Infections / immunology
  • Chlamydia Infections / microbiology
  • Chlamydia Infections / prevention & control
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / immunology*
  • Humans
  • Interferon-gamma / metabolism*
  • Membrane Proteins / metabolism*
  • Polymerase Chain Reaction
  • RNA, Bacterial / analysis


  • Antigens, Bacterial
  • Bacterial Vaccines
  • Cap1 protein, Chlamydia trachomatis
  • Membrane Proteins
  • RNA, Bacterial
  • Interferon-gamma