Overview of role of the immune system in the pathogenesis of inflammatory bowel disease

Adv Exp Med Biol. 2006;579:98-107. doi: 10.1007/0-387-33778-4_6.


Crohn's disease (CD) and ulcerative colitis (UC) are caused by the over-activity of the immune system. Current and novel therapies are designed to dampen these over-active responses. Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases. The former has the molecular imprints of a Th1 dominant cell-mediated hypersensitivity response whereas the latter appears to involve antibody-mediated hypersensitivity.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Cellular
  • Inflammatory Bowel Diseases / etiology
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / metabolism
  • Inflammatory Bowel Diseases / pathology*