Multifactorial approach and adherence to prescribed oral medications in patients with type 2 diabetes

Int J Clin Pract. 2006 Apr;60(4):422-8. doi: 10.1111/j.1368-5031.2006.00799.x.


The aims of this study were to assess adherence to oral hypoglycaemic/cardiovascular drugs and determine non-adherence predictors in type 2 diabetes patients. It was designed as a population-based cross-sectional study in which 90 patients from a primary care setting were studied. Pill count and self-report methods were used to measure adherence. Logistic regression analysis was performed to predict factors related to non-adherence. Adequate adherence to all drugs was found in 29 patients (35.4%; 95% confidence interval (CI) 25.0-45.7). Variables associated with non-adherence were HbA1c odds ratio (OR) 2.32 (95% CI: 1.09-4.95), systolic blood pressure OR 1.68 (95% CI: 1.08-2.62), total cholesterol OR 1.34 (95% CI: 1.08-1.66), number of pills OR 1.80 (95% CI: 1.26-2.55) and duration of disease OR 0.44 (CI 95%: 0.24-0.83). In conclusion, one in three patients had adequate adherence. Factors associated with non-adherence were duration of disease, complexity of drug regimen and inadequate control of cardiovascular risk factors.

MeSH terms

  • Administration, Oral
  • Aged
  • Antihypertensive Agents / therapeutic use
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Female
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Hypolipidemic Agents / therapeutic use
  • Logistic Models
  • Male
  • Patient Compliance*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Risk Factors


  • Antihypertensive Agents
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Platelet Aggregation Inhibitors