Regulation of apoptosis by insulin-like growth factor (IGF)-I

Cytokine Growth Factor Rev. 2006 Aug;17(4):305-23. doi: 10.1016/j.cytogfr.2006.02.002. Epub 2006 Apr 18.


IGF-I is important for fetal and post-natal development, but it also controls tissue homeostasis throughout life via regulation of cell proliferation and apoptosis. This review summarizes our current understanding of how IGF-I receptor signaling interferes with the apoptotic machinery of the cell. IGF-I acts at different control points of apoptosis, including the Bcl-2 family proteins, inhibitors of caspases and signaling of death-inducing receptors. The main focal point of IGF-I is the regulation of Bcl-2 family proteins. Several signaling pathways converge to both the phosphorylation and transcriptional regulation of these proteins. This phenomenon may explain the efficacy of IGF-I as an inhibitor of apoptosis in many different cell types and in the presence of different apoptogenic stimuli.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Humans
  • Insulin-Like Growth Factor I / physiology*
  • Insulin-Like Growth Factor I / therapeutic use
  • Receptor, IGF Type 1 / antagonists & inhibitors
  • Receptor, IGF Type 1 / metabolism
  • Signal Transduction


  • Insulin-Like Growth Factor I
  • Receptor, IGF Type 1