Phospholipase A in Gram-negative bacteria and its role in pathogenesis

Microbiology. 2006 May;152(Pt 5):1263-74. doi: 10.1099/mic.0.28609-0.


Phospholipase A (PLA) is one of the few enzymes present in the outer membrane of Gram-negative bacteria, and is likely to be involved in the membrane disruption processes that occur during host cell invasion. Both secreted and membrane-bound phospholipase A(2) activities have been described in bacteria, fungi and protozoa. Recently there have been increasing reports on the involvement of PLA in bacterial invasion and pathogenesis. This review highlights the latest findings on PLA as a virulence factor in Gram-negative bacteria.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Cell Membrane / enzymology
  • Gram-Negative Bacteria / enzymology*
  • Gram-Negative Bacteria / pathogenicity
  • Molecular Sequence Data
  • Phospholipases A / chemistry
  • Phospholipases A / genetics
  • Phospholipases A / physiology*
  • Virulence Factors / chemistry
  • Virulence Factors / genetics
  • Virulence Factors / physiology*


  • Virulence Factors
  • Phospholipases A