The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica

Infect Immun. 2006 May;74(5):3065-7. doi: 10.1128/IAI.74.5.3065-3067.2006.


We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / physiology
  • Cation Transport Proteins / physiology*
  • Cell Line
  • Hepcidins
  • Iron / metabolism
  • Macrophages / microbiology
  • Mice
  • Salmonella enterica / growth & development*


  • Antimicrobial Cationic Peptides
  • Cation Transport Proteins
  • Hamp protein, mouse
  • Hepcidins
  • metal transporting protein 1
  • Iron