doi: 10.1038/nsmb1081.
Epub 2006 Apr 23.
EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length
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- PMID: 16622410
- DOI: 10.1038/nsmb1081
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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length
Nat Struct Mol Biol.
2006 May.
Abstract
Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.
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