The principles of guiding by RNA: chimeric RNA-protein enzymes

Nat Rev Genet. 2006 Jun;7(6):475-82. doi: 10.1038/nrg1855.


The non-protein-coding transcriptional output of the cell is far greater than previously thought. Although the functions, if any, of the vast majority of these RNA transcripts remain elusive, out of those for which functions have already been established, most act as RNA guides for protein enzymes. Common features of these RNAs provide clues about the evolutionary constraints that led to the development of RNA-guided proteins and the specific biological environments in which target specificity and diversity are most crucial to the cell.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • RNA, Catalytic / genetics*
  • RNA, Untranslated* / genetics
  • RNA, Untranslated* / metabolism
  • RNA-Binding Proteins / physiology*
  • Transcription, Genetic / genetics*


  • RNA, Catalytic
  • RNA, Untranslated
  • RNA-Binding Proteins