Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions

Br J Cancer. 2006 Apr 24;94(8):1176-9. doi: 10.1038/sj.bjc.6603039.


The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD34 / analysis
  • Carcinoma, Non-Small-Cell Lung / blood supply*
  • Carcinoma, Non-Small-Cell Lung / classification
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Disease Progression
  • Humans
  • Imaging, Three-Dimensional*
  • Immunohistochemistry
  • Keratins / analysis
  • Lung Neoplasms / blood supply*
  • Lung Neoplasms / classification
  • Lung Neoplasms / pathology*
  • Neovascularization, Pathologic*
  • Staining and Labeling


  • Antigens, CD34
  • Keratins