Potent antibody therapeutics by design

Nat Rev Immunol. 2006 May;6(5):343-57. doi: 10.1038/nri1837.


Antibodies constitute the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. The generation of potent antibody therapeutics, which I review here, is an iterative design process that involves the generation and optimization of antibodies to improve their clinical potential.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / therapeutic use*
  • Drug Design*
  • Humans


  • Antibodies, Monoclonal