Long-term, tunneled, noncuffed central venous catheter in cancer patients (Vygon): safety, efficacy, and complications

Support Care Cancer. 2006 Nov;14(11):1141-6. doi: 10.1007/s00520-006-0065-2. Epub 2006 Apr 19.


Background: Totally implantable or partially cuffed central venous catheters (CVC) are commonly used in cancer patients, but they are often expensive and may produce complications. To minimize costs, we have been using a low-cost, partially tunneled, silicone elastomer catheter with no Dacron cuff or antireflux valve (Vygon) since 2001. This study is a retrospective investigation of our experience using the Vygon catheter as a long-term CVC in patients with malignancy.

Materials and methods: A total of 458 Vygon catheters (Nutricath, Vygon) were percutaneously inserted by an interventional radiologist in 302 cancer patients. The median duration of catheter use was 93 days, mean 164.3 days (range 1-789). Main patient characteristics were as follows: number of male/female patients, 166/136; median age, 51 years; hematological/nonhematological patients, 189/113.

Results: Early complications were pneumothorax in six and hematoma in twelve of 458 implants, respectively. Thirteen out of 302 patients developed a catheter-related thrombosis. One hundred and thirty-five of 458 Vygon catheters required removal because of catheter-related complications: 68 accidental losses, 37 cases of febrile neutropenia suspected to be catheter-related, ten catheter dislodgements, ten catheter malfunctions, four local infections, three thromboses, two catheter ruptures, and one allergic reaction.

Conclusion: Vygon catheters do not seem to induce more early and late complications as compared with other more expensive devices, except for disadvantage of the high incidence rate of accidental losses.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / administration & dosage*
  • Catheterization, Central Venous / adverse effects*
  • Catheterization, Central Venous / instrumentation*
  • Device Removal
  • Equipment Design
  • Equipment Failure
  • Equipment Safety
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Neoplasms / drug therapy
  • Prosthesis-Related Infections / etiology
  • Retrospective Studies
  • Subclavian Vein / surgery
  • Thrombosis / etiology
  • Time Factors
  • Treatment Outcome
  • Vena Cava, Superior / surgery


  • Antineoplastic Agents