Pd(0)-Catalyzed PMHS reductions of aromatic acid chlorides to aldehydes

Org Lett. 2006 Apr 27;8(9):1887-8. doi: 10.1021/ol060463v.

Abstract

[reaction: see text] Contrary to previous reports, polymethylhydrosiloxane (PMHS) under Pd(0) catalysis can efficiently reduce aryl acid chlorides to their corresponding aldehydes without requiring an additional reductant, provided the reactions are run in the presence of fluoride.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aldehydes / chemical synthesis*
  • Catalysis
  • Chlorides / chemistry*
  • Fluorides / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Palladium / chemistry*
  • Siloxanes / chemistry*

Substances

  • Aldehydes
  • Chlorides
  • Siloxanes
  • poly(methylhydrosiloxane)
  • Palladium
  • Fluorides