Scientific and medical aspects of ozone therapy. State of the art

Arch Med Res. 2006 May;37(4):425-35. doi: 10.1016/j.arcmed.2005.08.006.


The aim of this review is to dispel misconceptions and skepticism regarding ozone therapy and to clarify the biochemical and pharmacological mechanisms of action of ozone dissolved in biological fluids. The work performed in the last decade in our laboratory allows drawing a comprehensive framework for understanding and recommending ozone therapy in some diseases. It is hoped that this report will open a dialogue among clinical scientists and will inform physicians about the beneficial effects of ozone therapy.

Publication types

  • Review

MeSH terms

  • Alcohols / chemistry
  • Alcohols / metabolism
  • Animals
  • Body Fluids / chemistry
  • Body Fluids / drug effects
  • Humans
  • Hyperbaric Oxygenation
  • Lipid Peroxides / chemistry
  • Lipid Peroxides / metabolism
  • Ozone / administration & dosage
  • Ozone / chemistry
  • Ozone / therapeutic use*
  • Reactive Oxygen Species / chemistry
  • Reactive Oxygen Species / metabolism


  • Alcohols
  • Lipid Peroxides
  • Reactive Oxygen Species
  • alkoxyl radical
  • Ozone