Neurotensin receptors in human meningiomas

Ann Neurol. 1991 Nov;30(5):650-4. doi: 10.1002/ana.410300504.


We have investigated the presence of neurotensin receptors in human meningiomas by in vitro binding autoradiography. Ten of the 12 meningiomas tested displayed specific [3H]neurotensin binding. All meningothelial (n = 3) and transitional (n = 5) meningiomas were positive, whereas only 2 of the 4 fibroblastic meningiomas showed measurable concentrations of neurotensin binding sites. Within the tumors, [3H]neurotensin binding was preferentially observed in syncytial areas. Saturation experiments showed that the maximal binding capacity (Bmax) greatly varied among tumors, ranging from low values to more than 290 fmol/mg of protein. All positive tumors had neurotensin binding sites with a dissociation constant (kd) within the nanomolar range and a pharmacological specificity for [3H]neurotensin similar to neurotensin receptors.

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Female
  • Humans
  • Male
  • Meningeal Neoplasms / chemistry*
  • Meningioma / chemistry*
  • Neoplasm Proteins / analysis*
  • Neurotensin / metabolism*
  • Receptors, Neurotensin
  • Receptors, Neurotransmitter / analysis*


  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Receptors, Neurotensin
  • Receptors, Neurotransmitter
  • Neurotensin