Nicobrevin for smoking cessation

Cochrane Database Syst Rev. 2006 Apr 19;2006(2):CD005990. doi: 10.1002/14651858.CD005990.


Background: Nicobrevin is a proprietary product marketed as an aid to smoking cessation. It contains quinine, menthyl valerate, camphor and eucalyptus oil.

Objectives: The objective of this review was to assess the effects of Nicobrevin on long term smoking cessation

Search strategy: We searched the Cochrane Tobacco Addiction Group trials register.

Selection criteria: Randomized trials comparing Nicobrevin to placebo or an alternative therapeutic control, which reported smoking cessation with at least six months follow up.

Data collection and analysis: Data were sought on the outcome, method of randomization, and completeness of follow up.

Main results: We identified no trials meeting the full inclusion criteria including long-term follow up.

Authors' conclusions: There is no evidence available from long-term trials that Nicobrevin can aid smoking cessation.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Humans
  • Pentanoic Acids / therapeutic use*
  • Quinine / therapeutic use*
  • Smoking Cessation*
  • Smoking Prevention*
  • Terpenes / therapeutic use*


  • Pentanoic Acids
  • Terpenes
  • nicobrevin
  • Quinine