Combination pharmacotherapy for severe neonatal pulmonary hypertension

J Paediatr Child Health. 2006 Apr;42(4):219-20. doi: 10.1111/j.1440-1754.2006.00835.x.

Abstract

Pulmonary hypertension can complicate the early clinical course in newborn infants with congenital diaphragmatic hernia. We report the successful use of combination therapy with enteral sildenafil and intravenous prostaglandin E1 in a preterm infant with severe pulmonary hypertension and right heart failure early after congenital diaphragmatic hernia repair.

Publication types

  • Case Reports

MeSH terms

  • Alprostadil / administration & dosage
  • Alprostadil / therapeutic use*
  • Drug Therapy, Combination
  • Heart Failure / etiology
  • Heart Failure / prevention & control
  • Hernia, Diaphragmatic / complications
  • Hernia, Diaphragmatic / surgery*
  • Hernias, Diaphragmatic, Congenital*
  • Humans
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / drug therapy*
  • Infant, Newborn
  • Piperazines / administration & dosage
  • Piperazines / therapeutic use*
  • Postoperative Care
  • Premature Birth
  • Purines / administration & dosage
  • Purines / therapeutic use
  • Sildenafil Citrate
  • Sulfones / administration & dosage
  • Sulfones / therapeutic use*
  • Treatment Outcome
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use*

Substances

  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Sildenafil Citrate
  • Alprostadil