Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report

Cancer J. Mar-Apr 2006;12(2):155-9.


This retrospective preliminary review evaluated the efficacy and toxicity of fractionated proton radiotherapy in the management of pediatric craniopharyngioma.

Methods: Sixteen patients, aged 7-34 years, were treated with proton-beam radiation. All had undergone at least one tumor resection. Seven patients underwent repeat resection for recurrence; one had previous x-ray radiotherapy. A daily dose of 1.8 cobalt gray equivalent was used to give a total dose in the range of 50.4-59.4 cobalt gray equivalent.

Results: Local control was achieved in 14 of 15 patients. Twelve of 15 patients survived. There were few acute side effects. Long-term complications included newly diagnosed panhypopituitarism, a cerebrovascular accident from which the patient fully recovered, and an out-of-proton-field meningioma in the single patient who received previous radiotherapy.

Discussion: Fractionated proton radiotherapy is an effective treatment for children with craniopharyngioma. Longer follow-up is needed to evaluate late complications.

MeSH terms

  • Adolescent
  • Adult
  • California / epidemiology
  • Child
  • Craniopharyngioma / mortality
  • Craniopharyngioma / pathology
  • Craniopharyngioma / therapy*
  • Dose Fractionation, Radiation
  • Female
  • Humans
  • Male
  • Pituitary Neoplasms / mortality
  • Pituitary Neoplasms / pathology
  • Pituitary Neoplasms / therapy*
  • Proton Therapy*
  • Radiotherapy, Adjuvant
  • Radiotherapy, Conformal / methods*
  • Retrospective Studies
  • Salvage Therapy / methods


  • Protons