Dynamic nucleosomes and gene transcription

Trends Genet. 2006 Jun;22(6):320-9. doi: 10.1016/j.tig.2006.03.008. Epub 2006 May 2.


Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Amino Acid Sequence
  • Animals
  • Chromatin / genetics
  • Chromatin / physiology*
  • Dimerization
  • Histone Deacetylases / physiology
  • Histones / physiology*
  • Humans
  • Methylation
  • Molecular Sequence Data
  • Nucleosomes / genetics
  • Nucleosomes / physiology*
  • Transcription, Genetic*


  • Chromatin
  • Histones
  • Nucleosomes
  • Histone Deacetylases