High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series

Eur Urol. 2006 Sep;50(3):498-505. doi: 10.1016/j.eururo.2006.03.026. Epub 2006 Mar 29.


Objectives: We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy.

Materials and methods: Between 2001 and 2004, saturation biopsies (average of 24 cores) were performed in 161 men with persistently elevated prostate specific antigen (PSA) level (median, 9 ng/ml). All had at least two previously negative, eight-core biopsy sessions. PCa predictors on saturation biopsy were integrated within multivariate nomograms.

Results: PCa detection was 41% (n=66 of 161). PSA density and transition zone volume were the most significant predictors of PCa on saturation biopsy. The accuracy of the nomogram with the best performance characteristics was 72%.

Conclusions: Saturation biopsy may be indicated in men with a persistent suspicion of PCa. High-risk individuals can be identified accurately with our nomogram.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biopsy / methods*
  • Carcinoma / diagnosis*
  • Carcinoma / epidemiology*
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Models, Statistical
  • Multivariate Analysis
  • Nomograms
  • Prostate-Specific Antigen / blood
  • Prostatectomy / statistics & numerical data
  • Prostatic Intraepithelial Neoplasia / diagnosis
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / epidemiology*


  • Prostate-Specific Antigen