Biology of vascular endothelial growth factors

FEBS Lett. 2006 May 22;580(12):2879-87. doi: 10.1016/j.febslet.2006.03.087. Epub 2006 Apr 17.


Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arthritis, Rheumatoid / physiopathology
  • Humans
  • Lymphatic Vessels / cytology
  • Lymphedema / physiopathology
  • Neoplasms / blood supply*
  • Neovascularization, Pathologic
  • Vascular Endothelial Growth Factor A / classification
  • Vascular Endothelial Growth Factor A / physiology*
  • Wound Healing / physiology


  • Vascular Endothelial Growth Factor A