Health Utilities Index mark 3 demonstrated construct validity in a population-based sample with type 2 diabetes

J Clin Epidemiol. 2006 May;59(5):472-7. doi: 10.1016/j.jclinepi.2005.09.010. Epub 2006 Mar 14.


Objective: To assess the cross-sectional construct validity of the Health Utilities Index mark 3 (HUI3) in type 2 diabetes using population health survey data.

Study design and setting: Data used were from 5,134 adult respondents of Cycle 1.1 (2000-2001) of the Canadian Community Health Survey (CCHS) with type 2 diabetes. Analyses of covariance models were used to assess differences in overall and single-attribute HUI3 scores between groups hypothesized a priori to differ in HRQL. The association between health-care resource use (i.e., hospitalizations and physician and emergency room visits) and overall HUI3 scores was assessed using logistic regression models.

Results: For overall HUI3 scores, clinically important and statistically significant differences were observed between all groups expected to differ in HRQL. Depression was the comorbidity associated with the largest deficit (-0.17; 95% confidence interval CI=-0.22, -0.12), followed by stroke (-0.15; 95% CI=-0.21, -0.10) and heart disease (-0.08; 95% CI=-0.11, -0.05). Insulin use and comorbidities were associated with clinically important deficits in pain. Overall HUI3 scores were significantly predictive of all three categories of health-care resource use.

Conclusion: Observed differences between groups contribute further evidence of the construct validity of the HUI3 in type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Canada / epidemiology
  • Cross-Sectional Studies
  • Diabetes Complications / epidemiology
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / psychology
  • Emergency Medical Services
  • Female
  • Health Surveys
  • Hospitalization
  • Humans
  • Insulin / therapeutic use
  • Logistic Models
  • Male
  • Middle Aged
  • Patient Acceptance of Health Care / psychology
  • Quality of Life
  • Reproducibility of Results
  • Severity of Illness Index
  • Time Factors


  • Insulin