Serum molybdenum concentration in healthy Japanese adults determined by inductively coupled plasma-mass spectrometry

J Trace Elem Med Biol. 2006;20(1):19-23. doi: 10.1016/j.jtemb.2005.10.003. Epub 2005 Dec 13.


The serum molybdenum (Mo) concentrations in 70 Japanese adults (35 males and 35 females) not receiving any medical care or treatment were determined by inductively coupled plasma-mass spectrometry. Serum Mo concentration in the subjects ranged from <0.1 to 9.11 ng/mL. More than half (55.7%) of the subjects showed values of less than 1 ng/mL and only 6 (8.6%) subjects showed more than 2 ng/mL. The mean+/-SD, geometrical mean (GM), range of GM+/-geometrical SD (GSD) and median value were 1.21+/-1.34, 0.81, 0.30 to 2.16, and 0.90 ng/mL, respectively. Among age, body mass index and several serum biochemical values, activities of aspartate aminotransferase and alanine aminotransferase showed significant associations with serum Mo; 15 subjects suspected of having liver dysfunction showed significantly higher serum Mo than others. We propose a range of 0.10-4.73 ng/mL, estimated as a range of GM+/-2GSD of serum Mo in the remaining 55 subjects without liver dysfunction, as a reference range of serum Mo in Japanese healthy adults.

MeSH terms

  • Adult
  • Age Distribution
  • Alanine Transaminase / blood
  • Aspartate Aminotransferases / blood
  • Body Mass Index
  • Female
  • Humans
  • Japan
  • Male
  • Mass Spectrometry / methods
  • Middle Aged
  • Molybdenum / blood*
  • Reference Values
  • Sensitivity and Specificity


  • Molybdenum
  • Aspartate Aminotransferases
  • Alanine Transaminase