Peri-implant inflammation defined by the implant-abutment interface

J Dent Res. 2006 May;85(5):473-8. doi: 10.1177/154405910608500515.


An implant-abutment interface at the alveolar bone crest is associated with sustained peri-implant inflammation; however, whether magnitude of inflammation is proportionally dependent upon interface position remains unknown. This study compared the distribution and density of inflammatory cells surrounding implants with a supracrestal, crestal, or subcrestal implant-abutment interface. All implants developed a similar pattern of peri-implant inflammation: neutrophilic polymorphonuclear leukocytes (neutrophils) maximally accumulated at or immediately coronal to the interface. However, peri-implant neutrophil accrual increased progressively as the implant-abutment interface depth increased, i.e., subcrestal interfaces promoted a significantly greater maximum density of neutrophils than did supracrestal interfaces (10,512 +/- 691 vs. 2398 +/- 1077 neutrophils/mm(2)). Moreover, inflammatory cell accumulation below the original bone crest was significantly correlated with bone loss. Thus, the implant-abutment interface dictates the intensity and location of peri-implant inflammatory cell accumulation, a potential contributing component in the extent of implant-associated alveolar bone loss.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Bone Loss / etiology*
  • Animals
  • Dental Abutments
  • Dental Implantation, Endosseous / adverse effects*
  • Dental Implants / adverse effects*
  • Dental Prosthesis Design / adverse effects
  • Dogs
  • Leukocyte Count
  • Male
  • Mandibular Diseases / etiology
  • Neutrophils
  • Periodontitis / etiology*
  • Statistics, Nonparametric


  • Dental Implants