Regulation of DNA repair by ubiquitylation

Nat Rev Mol Cell Biol. 2006 May;7(5):323-34. doi: 10.1038/nrm1908.


The process of ubiquitylation is best known for its role in targeting proteins for degradation by the proteasome. However, recent studies of DNA-repair and DNA-damage-response pathways have significantly broadened the scope of the role of ubiquitylation to include non-proteolytic functions of ubiquitin. These pathways involve the monoubiquitylation of key DNA-repair proteins that have regulatory functions in homologous recombination and translesion DNA synthesis, and involve the polyubiquitylation of nucleotide-excision-repair proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / biosynthesis
  • DNA Damage
  • DNA Repair / physiology*
  • Fanconi Anemia / metabolism
  • Humans
  • SUMO-1 Protein / metabolism
  • Ubiquitin / metabolism*


  • SUMO-1 Protein
  • Ubiquitin
  • DNA