ARF proteins: roles in membrane traffic and beyond

Nat Rev Mol Cell Biol. 2006 May;7(5):347-58. doi: 10.1038/nrm1910.


The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the structure of actin at membrane surfaces. Recent advances in our understanding of the signalling pathways that are regulated by ARF1 and ARF6, two of the best characterized ARF proteins, provide a molecular context for ARF protein function in fundamental biological processes, such as secretion, endocytosis, phagocytosis, cytokinesis, cell adhesion and tumour-cell invasion.

Publication types

  • Review

MeSH terms

  • ADP-Ribosylation Factors / metabolism*
  • Actins / metabolism
  • Animals
  • Biological Transport
  • Golgi Apparatus / metabolism
  • Intracellular Membranes / metabolism*
  • Secretory Vesicles / metabolism


  • Actins
  • ADP-Ribosylation Factors