Is there more to BARD1 than BRCA1?

Nat Rev Cancer. 2006 May;6(5):382-91. doi: 10.1038/nrc1878.


It has been over a decade since mutations in BRCA1 and BRCA2 were found to be associated with a small number of familial breast cancer cases. BRCA1 is a large protein that interacts with many other proteins that have diverse functions, so it has been a challenge to determine how defects in its function could lead to cancer. One particular protein, BARD1, seems to be an important regulator of the tumour-suppressor function of BRCA1, as well as acting as a tumour suppressor itself. BARD1 is indispensable for cell viability, so loss-of-function mutations are rare, but mutations and truncations that alter its function might be involved in the pathogenesis of breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • BRCA1 Protein / genetics*
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / genetics*
  • Female
  • Forecasting
  • Genetic Predisposition to Disease
  • Germ-Line Mutation / genetics*
  • Humans
  • Tumor Suppressor Proteins / genetics*
  • Ubiquitin-Protein Ligases / genetics*


  • BRCA1 Protein
  • Tumor Suppressor Proteins
  • BARD1 protein, human
  • Ubiquitin-Protein Ligases