Endocytosis and signals for internalization

Curr Opin Cell Biol. 1991 Aug;3(4):634-41. doi: 10.1016/0955-0674(91)90034-v.

Abstract

The most important recent advance in the field of endocytosis has been the identification of the internalization signals of several constitutively recycling receptors. Common structural features and chemistry of internalization sequences have been defined, and an exposed tight turn has been implicated as the conformational recognition motif for endocytosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cattle
  • Coated Pits, Cell-Membrane / metabolism
  • Endocytosis*
  • Humans
  • Lipoproteins, LDL / metabolism
  • Lysosomes / metabolism
  • Mannosephosphates / metabolism
  • Membrane Glycoproteins / metabolism
  • Molecular Sequence Data
  • Molecular Structure
  • Protein Conformation
  • Receptor, IGF Type 2
  • Receptors, Cell Surface / metabolism*
  • Receptors, LDL / metabolism*
  • Receptors, Transferrin / metabolism*
  • Signal Transduction*
  • Transferrin / metabolism

Substances

  • Lipoproteins, LDL
  • Mannosephosphates
  • Membrane Glycoproteins
  • Receptor, IGF Type 2
  • Receptors, Cell Surface
  • Receptors, LDL
  • Receptors, Transferrin
  • Transferrin
  • mannose-6-phosphate