Molecular recognition and targeting of lysosomal proteins

Curr Opin Cell Biol. 1991 Aug;3(4):642-6. doi: 10.1016/0955-0674(91)90035-w.

Abstract

Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP-binding protein and that the insulin-like growth factor-II-induced activation of the GTP-binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes. In mouse, the gene for the large mannose-6-phosphate receptor is maternally imprinted.

Publication types

  • Review

MeSH terms

  • Animals
  • Coated Pits, Cell-Membrane / metabolism
  • Embryonic and Fetal Development
  • Enzymes / metabolism
  • Enzymes / pharmacology
  • Fungal Proteins / metabolism
  • GTP-Binding Proteins / metabolism*
  • Genes, Lethal
  • Humans
  • Insulin-Like Growth Factor II / antagonists & inhibitors
  • Insulin-Like Growth Factor II / physiology*
  • Lysosomes / metabolism*
  • Mammals / metabolism
  • Mannosephosphates / metabolism*
  • Mannosephosphates / pharmacology
  • Membrane Proteins / metabolism
  • Mice / embryology
  • Mice / genetics
  • Mucolipidoses / metabolism
  • Phosphorylation
  • Phosphotransferases / metabolism
  • Protein Binding
  • Protein Kinases / metabolism
  • Protein Processing, Post-Translational
  • Receptor, IGF Type 2
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction*

Substances

  • Enzymes
  • Fungal Proteins
  • Mannosephosphates
  • Membrane Proteins
  • Receptor, IGF Type 2
  • Receptors, Cell Surface
  • mannose-6-phosphate
  • Insulin-Like Growth Factor II
  • Phosphotransferases
  • Protein Kinases
  • GTP-Binding Proteins