Abstract
Sorting of secreted proteins into dense-core secretory granules may involve selective aggregation of regulated secretory proteins, rather than a conventional sortase. Synaptic vesicles, which mediate paracrine communication between adjacent cells, appear to arise by a modification of the early endosome pathway. Targeting to the cell surface involves the actin-based cytoskeleton and small GTP-binding proteins.
MeSH terms
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Animals
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Aplysia / metabolism
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Cell Communication
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Cell Compartmentation
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Cells, Cultured
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Ciliophora / physiology
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Cytoplasmic Granules / metabolism*
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Cytoskeleton / physiology
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Exocytosis
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GTP-Binding Proteins / physiology
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Membrane Fusion
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Membrane Lipids / physiology
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Membrane Proteins / metabolism
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Models, Biological
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Phospholipids / physiology
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Protein Processing, Post-Translational
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Proteins / metabolism*
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Receptors, Cell Surface / metabolism
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Synaptic Vesicles / metabolism*
Substances
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Membrane Lipids
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Membrane Proteins
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Phospholipids
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Proteins
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Receptors, Cell Surface
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GTP-Binding Proteins