Secretory granule and synaptic vesicle formation

Curr Opin Cell Biol. 1991 Aug;3(4):654-60. doi: 10.1016/0955-0674(91)90037-y.

Abstract

Sorting of secreted proteins into dense-core secretory granules may involve selective aggregation of regulated secretory proteins, rather than a conventional sortase. Synaptic vesicles, which mediate paracrine communication between adjacent cells, appear to arise by a modification of the early endosome pathway. Targeting to the cell surface involves the actin-based cytoskeleton and small GTP-binding proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Aplysia / metabolism
  • Cell Communication
  • Cell Compartmentation
  • Cells, Cultured
  • Ciliophora / physiology
  • Cytoplasmic Granules / metabolism*
  • Cytoskeleton / physiology
  • Exocytosis
  • GTP-Binding Proteins / physiology
  • Membrane Fusion
  • Membrane Lipids / physiology
  • Membrane Proteins / metabolism
  • Models, Biological
  • Phospholipids / physiology
  • Protein Processing, Post-Translational
  • Proteins / metabolism*
  • Receptors, Cell Surface / metabolism
  • Synaptic Vesicles / metabolism*

Substances

  • Membrane Lipids
  • Membrane Proteins
  • Phospholipids
  • Proteins
  • Receptors, Cell Surface
  • GTP-Binding Proteins