Emerging therapies for the treatment and prevention of otitis media

Expert Opin Emerg Drugs. 2006 May;11(2):251-64. doi: 10.1517/14728214.11.2.251.


Otitis media is one of the most common disorders occurring in children, and there is growing concern that bacteria are quickly becoming resistant to antimicrobials. As a result, global antibiotic treatment is no longer the standard of care and treatment of otitis media has changed dramatically in the last decade. In addition to new antimicrobials currently in development, the effects of the pneumococcal conjugate vaccine are just beginning to be understood. Furthermore, new surgical techniques are for the first time being tested as alternatives for tympanostomy tubes for recurrent acute otitis media. This review discusses current and emerging otitis media therapeutics, with particular attention to acute otitis media. Topics include antimicrobial use, antimicrobial resistance, effects of vaccination and new surgical techniques.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Drugs, Investigational / chemistry
  • Drugs, Investigational / pharmacology
  • Drugs, Investigational / therapeutic use*
  • Humans
  • Otitis Media / drug therapy*
  • Otitis Media / microbiology
  • Otitis Media / prevention & control*
  • Pneumococcal Vaccines / chemistry
  • Pneumococcal Vaccines / pharmacology
  • Pneumococcal Vaccines / therapeutic use


  • Anti-Bacterial Agents
  • Drugs, Investigational
  • Pneumococcal Vaccines