Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris

Am J Cardiol. 2006 May 1;97(9):1322-5. doi: 10.1016/j.amjcard.2005.11.073. Epub 2006 Mar 20.


This study examined whether coronary focal vasospasm occurs in a nonuniform distribution within the coronary tree and whether a longitudinal plaque distribution pattern is present in patients with vasospastic angina using 3-dimensional intravascular ultrasound analysis. Of 121 patients with clinically suspected angina without fixed stenosis in the coronary arteries, vasospasm was provoked in 82 patients with 92 lesions (42 focal, 50 diffuse) by intravenous ergonovine maleate injection. Most focal vasospasms occurred in the proximal third of the coronary arteries (proximal 28, mid 8, distal 6, p <0.01), corresponding to the historical high-risk zones for acute coronary occlusion. More plaque burden also existed in the proximal third of the coronary arteries in patients with focal vasospasm.

MeSH terms

  • Angina Pectoris / diagnostic imaging*
  • Coronary Angiography
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Vasospasm / chemically induced*
  • Coronary Vasospasm / diagnostic imaging*
  • Coronary Vessels / diagnostic imaging
  • Electrocardiography
  • Ergonovine*
  • Female
  • Humans
  • Imaging, Three-Dimensional
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Ultrasonography, Interventional
  • Vasoconstrictor Agents*


  • Vasoconstrictor Agents
  • Ergonovine