Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

J Med Chem. 2006 May 4;49(9):2845-9. doi: 10.1021/jm0601856.

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemical synthesis*
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Antimalarials / toxicity
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / toxicity
  • Drug Design*
  • Ferrous Compounds / chemical synthesis
  • Ferrous Compounds / chemistry*
  • Ferrous Compounds / pharmacology*
  • Ferrous Compounds / toxicity
  • HIV-1 / drug effects
  • Molecular Structure
  • Plasmodium falciparum / drug effects
  • Quinolines / chemical synthesis
  • Quinolines / chemistry*
  • Quinolines / pharmacology*
  • Quinolines / toxicity
  • SARS Virus / drug effects

Substances

  • Antimalarials
  • Antiviral Agents
  • Ferrous Compounds
  • Quinolines