Nuclear targeting sequences--a consensus?

Trends Biochem Sci. 1991 Dec;16(12):478-81. doi: 10.1016/0968-0004(91)90184-w.


Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been regarded as the model; however, many nuclear targeting sequences appear to be more complex. We suggest in this review that, despite this diversity, a consensus bipartite motif can be identified.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Viral, Tumor / metabolism
  • Biological Transport
  • Carrier Proteins / metabolism*
  • Consensus Sequence
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins / metabolism*
  • Sequence Homology, Nucleic Acid
  • Simian virus 40 / metabolism


  • Antigens, Viral, Tumor
  • Carrier Proteins
  • Nuclear Proteins