Targeting lymphangiogenesis to prevent tumour metastasis

Br J Cancer. 2006 May 22;94(10):1355-60. doi: 10.1038/sj.bjc.6603120.

Abstract

Recent studies involving animal models of cancer and clinicopathological analyses of human tumours suggest that the growth of lymphatic vessels (lymphangiogenesis) in or nearby tumours is associated with the metastatic spread of cancer. The best validated molecular signalling system for tumour lymphangiogenesis involves the secreted proteins vascular endothelial growth factor-C (VEGF-C) and VEGF-D that induce growth of lymphatic vessels via activation of VEGF receptor-3 (VEGFR-3) localised on the surface of lymphatic endothelial cells. In this review, we discuss the evidence supporting a role for this signalling system in the spread of cancer and potential approaches for blocking this system to prevent tumour metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphangiogenesis / drug effects*
  • Lymphatic Metastasis / prevention & control
  • Lymphatic Vessels / physiology
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Vascular Endothelial Growth Factor C / physiology
  • Vascular Endothelial Growth Factor D / physiology
  • Vascular Endothelial Growth Factor Receptor-3 / physiology

Substances

  • Vascular Endothelial Growth Factor C
  • Vascular Endothelial Growth Factor D
  • Vascular Endothelial Growth Factor Receptor-3