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. 2006 Apr 27;440(7088):1194-8.
doi: 10.1038/nature04728.

The DNA Sequence, Annotation and Analysis of Human Chromosome 3

Donna M Muzny  1 Steven E SchererRajinder KaulJing WangJun YuRalf SudbrakChristian J BuhayRui ChenAndrew CreeYan DingShannon Dugan-RochaRachel GillPreethi GunaratneR Alan HarrisAlicia C HawesJudith HernandezAnne V HodgsonJennifer HumeAndrew JacksonZiad Mohid KhanChristie Kovar-SmithLora R LewisRyan J LozadoMichael L MetzkerAleksandar MilosavljevicGeorge R MinerMargaret B MorganLynne V NazarethGraham ScottErica SodergrenXing-Zhi SongDavid SteffenSharon WeiDavid A WheelerMathew W WrightKim C WorleyYe YuanZhengdong ZhangCharles Q AdamsM Ali Ansari-LariMulu AyeleMary J BrownGuan ChenZhijian ChenJames ClendenningKerstin P Clerc-BlankenburgRunsheng ChenZhu ChenClay DavisOliver DelgadoHuyen H DinhWei DongHeather DraperStephen ErnstGang FuManuel L Gonzalez-GarayDawn K GarciaWill GillettJun GuBailin HaoEric HaugenPaul HavlakXin HeSteffen HennigSongnian HuWei HuangLaronda R JacksonLeni S JacobSusan H KellyMichael KubeRuth LevyZhangwan LiBin LiuJing LiuWen LiuJing LuManjula MaheshwariBao-Viet NguyenGeoffrey O OkwuonuAnthony PalmeiriShiran PasternakLesette M PerezKaren A PhelpsFarah J H PlopperBoqin QiangChristopher RaymondRuben RodriguezChannakhone SaenphimmachakJireh SantibanezHua ShenYan ShenSandhya SubramanianPaul E TaborDaniel VerduzcoLenee WaldronJian WangJun WangQiaoyan WangGabrielle A WilliamsGane K-S WongZhijian YaoJingKun ZhangXiuqing ZhangGuoping ZhaoJianling ZhouYang ZhouDavid NelsonHans LehrachRichard ReinhardtSusan L NaylorHuanming YangMaynard OlsonGeorge WeinstockRichard A Gibbs
Affiliations

The DNA Sequence, Annotation and Analysis of Human Chromosome 3

Donna M Muzny et al. Nature. .

Abstract

After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion.

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