Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006 Sep 15;119(6):1508-10.
doi: 10.1002/ijc.21993.

Self-reported Goiter Is Associated With a Significantly Increased Risk of Gastric Noncardia Adenocarcinoma in a Large Population-Based Chinese Cohort

Affiliations
Free article
Randomized Controlled Trial

Self-reported Goiter Is Associated With a Significantly Increased Risk of Gastric Noncardia Adenocarcinoma in a Large Population-Based Chinese Cohort

Christian C Abnet et al. Int J Cancer. .
Free article

Abstract

Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant. Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer. We examined the association between self-reported goiter and upper gastrointestinal cancer in a Chinese cohort of 29,584 adults. Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30). We also found a borderline, insignificant increased risk of esophageal squamous cell carcinoma, HR (95% CI) 1.37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

LinkOut - more resources

Feedback