Effect of Helicobacter pylori infection on deep vein thrombosis seen in patients with Behçet's disease

East Afr Med J. 2006 Jan;83(1):49-51. doi: 10.4314/eamj.v83i1.9361.


Objective: To investigate the role of homocysteine metabolism due to Helicobacter pylori infection on the development of deep vein thrombosis (DVT) in patients with Behcet's disease (BD).

Design: Prospective clinical study.

Setting: Teaching hospital.

Subject: Fifty-five patients with BD divided into groups, with DVT and without DVT, 19 healthy individuals and 18 patients with coronary artery disease (CAD) were enrolled into the study.

Interventions: Plasma homocysteine and Hp seropositivity were determined.

Results: There was significant Hp positivity in all groups (p > 0.05). Homocysteine levels were not significantly different for each group except patients with CAD (p > 0.05).

Conclusion: There was no difference for frequency of Hp infection in all groups. We conclude that Hp does not influence DVT seen in BD via homocysteine metabolism, but the methinnin-loading test would be appropriate for enlighting patients whose fasting plasma homocysteine levels are found to be normal.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Behcet Syndrome / complications
  • Behcet Syndrome / microbiology*
  • Case-Control Studies
  • Female
  • Helicobacter Infections / complications
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / isolation & purification*
  • Homocysteine / metabolism*
  • Hospitals, Teaching
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Venous Thrombosis / complications
  • Venous Thrombosis / microbiology*


  • Homocysteine