Histone mediated gene activation in Toxoplasma gondii

Mol Biochem Parasitol. 2006 Aug;148(2):109-16. doi: 10.1016/j.molbiopara.2006.03.010. Epub 2006 Apr 18.


DNA processes, including transcriptional activation, are largely governed by histone modifications. For most eukaryotes, chromatin-remodeling machines have been identified that move, replace, or decorate histones. Recent studies have shed some important light on similar machinery operating in apicomplexan parasites, including the opportunistic pathogen Toxoplasma gondii. Here we present a synthesis of the current knowledge of histone mediated gene expression in Toxoplasma, particularly in the context of parasite differentiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Histones / metabolism*
  • Protozoan Proteins / genetics*
  • Protozoan Proteins / metabolism
  • Toxoplasma / genetics
  • Toxoplasma / growth & development*
  • Toxoplasma / metabolism
  • Transcriptional Activation


  • Histones
  • Protozoan Proteins