Isolated recurrence of intracerebral granulocytic sarcoma in acute lymphoblastic leukemia: a case report

J Neurooncol. 2006 Oct;80(1):101-4. doi: 10.1007/s11060-006-9163-8. Epub 2006 Apr 28.


Intracranial granulocytic sarcoma (chloroma) may occur rarely in leukemia. A 27-year-old male presented with an isolated recurrence of granulocytic sarcoma manifesting as an intraaxial mass 27 months after complete remission of acute lymphoblastic leukemia. He was admitted due to a severe headache and blurred vision. Brain magnetic resonance imaging demonstrated an enhanced mass which was initially interpreted as an extraaxial tumor in the right temporal region. Because of increased intracranial pressure and the mass effect, open biopsy with surgical resection was performed. The biopsy result indicated that intraaxial lymphoblastic leukemia infiltration had caused CNS relapse. Although granulocytic sarcoma occurs primarily in patients with acute myelogenous leukemia, the authors report a rare case of intraparenchymal granulocytic sarcoma in acute lymphoblastic leukemia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / complications
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery
  • Headache / etiology
  • Humans
  • Intracranial Hypertension / etiology
  • Intracranial Hypertension / surgery
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Recurrence, Local / pathology*
  • Neurosurgical Procedures
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Sarcoma, Myeloid / complications
  • Sarcoma, Myeloid / pathology*
  • Sarcoma, Myeloid / surgery
  • Ventriculoperitoneal Shunt
  • Vision Disorders / etiology