Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer

Mol Cell Endocrinol. 2006 Jun 27;252(1-2):241-6. doi: 10.1016/j.mce.2006.03.018. Epub 2006 Apr 27.

Abstract

The insulin-like growth factor-I receptor (IGF-IR) has an important role in normal mammary gland growth and morphogenesis. In addition, the IGF-IR has been implicated in the initiation and progression of breast cancer. Previous studies have indicated that acquisition of the malignant phenotype in breast cancer is initially IGF-IR dependent. Most breast cancer-derived cell lines and primary tumors express high levels of IGF-IR mRNA and protein, whereas metastatic stages are usually associated with a decrease in IGF-IR levels. Transcription of the IGF-IR gene is controlled by complex interactions involving DNA-binding and non DNA-binding transcription factors. This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Breast Neoplasms / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Genes, BRCA1
  • Genes, p53
  • Humans
  • Receptor, IGF Type 1 / genetics*
  • Transcription Factors / metabolism
  • Transcription, Genetic*

Substances

  • Transcription Factors
  • Receptor, IGF Type 1