Left visuo-spatial neglect is a well-recognized predictor of poor functional outcome following right hemisphere stroke. Over the past 60 years, 18 different methods have been described and evaluated aimed at reducing the effects of this impairment. Although there are some grounds for optimism particularly in terms of short-term impairment-based effects, the range and degree of disability borne by many patients remain high and the clinical effectiveness of the different methods viewed in terms of long-lasting functional improvement (i.e. improvement of disabilities or handicap) is not clear. A systematic review of the available clinically relevant literature, using comparative and stringent levels of evidence, indicates that visual scanning training (VST), trunk rotation (TR) or repeated neck muscle vibrations (NMV) when associated with an extensive training program, mental imagery training, video feedback training and prism adaptation (PA) can be recommended for the rehabilitation of patients with left neglect. More studies however are needed to determine the optimal paradigm of limb activation (LA) eliciting a sustained functional improvement. Sensory stimulations alone and Fresnel prisms do not appear to be functionally relevant. For the other methods, the actual literature is not sufficient to conclude whether or not a long-term functional improvement can be achieved.