Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Biochim Biophys Acta. 2006 Apr;1761(4):474-83. doi: 10.1016/j.bbalip.2006.03.010. Epub 2006 Apr 7.


Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases. Although multiple DHHC proteins are found in eukaryotes, characterization has been examined for only a few. Here, we have cloned all the yeast and human DHHC genes and investigated their intracellular localization and tissue-specific expression. Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole. Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / classification
  • Acyltransferases / genetics
  • Acyltransferases / metabolism*
  • Cell Line
  • Humans
  • Isoenzymes / classification
  • Isoenzymes / genetics
  • Isoenzymes / metabolism*
  • Phylogeny
  • Saccharomyces cerevisiae / chemistry*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / classification
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Subcellular Fractions / enzymology
  • Tissue Distribution


  • Isoenzymes
  • Saccharomyces cerevisiae Proteins
  • Acyltransferases