Genetic overlap between P300, P50, and duration mismatch negativity

Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):336-43. doi: 10.1002/ajmg.b.30318.


Mismatch Negativity (MMN), P300, and P50 suppression event-related potential (ERP) components measure intermediate stages of information processing but little is known of how they relate to each other genetically. The present study used multivariate genetic model fitting analytic techniques in 46 monozygotic and 32 dizygotic twin pairs. P300, P50 suppression, and MMN were recorded using a 19-channel electroencephalograph (EEG). Zygosity was determined using DNA genotyping. Little evidence for either genetic or environmental association between each of the three ERP paradigms was found. This result suggests that P300, MMN, and P50 suppression serve to evaluate different brain information processing functions that may be mediated by distinct neurobiological mechanisms which in turn are influenced by different sets of genes. Within paradigm, P300 amplitude and latency shared about half of their genetic effects.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Electroencephalography / methods
  • Event-Related Potentials, P300 / genetics*
  • Event-Related Potentials, P300 / physiology
  • Evoked Potentials / genetics*
  • Evoked Potentials / physiology
  • Evoked Potentials, Auditory / genetics*
  • Evoked Potentials, Auditory / physiology
  • Female
  • Humans
  • Male
  • Models, Genetic
  • Multivariate Analysis
  • Twins, Dizygotic / genetics
  • Twins, Dizygotic / physiology
  • Twins, Monozygotic / genetics
  • Twins, Monozygotic / physiology