Comorbid diagnoses in patients meeting criteria for the schizophrenia prodrome

Schizophr Res. 2006 Jul;85(1-3):124-31. doi: 10.1016/j.schres.2006.03.034. Epub 2006 May 2.


While schizophrenia is often associated with a variety of concurrent psychiatric symptoms, little attention has been paid to the prevalence of psychiatric comorbidity in prodromal patients. The current study examines the presence of comorbid current and lifetime psychiatric conditions in prospectively identified prodromal patients. The results suggest that like their schizophrenic counterparts, prodromal patients experience a wide array of comorbid psychiatric syndromes, with the most common being Major Depressive Disorder and Cannabis Dependence. Results also suggest that Cannabis Dependence may be more common among prodromal versus help-seeking control patients. These findings lay the groundwork for further examination of the role that comorbid conditions play in the development, course, and severity of schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Comorbidity
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / epidemiology*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Humans
  • Male
  • Marijuana Abuse / diagnosis
  • Marijuana Abuse / epidemiology*
  • Middle Aged
  • Prospective Studies
  • Schizophrenia / diagnosis
  • Schizophrenia / epidemiology*
  • Severity of Illness Index