Regulating the licensing of DNA replication origins in metazoa

Curr Opin Cell Biol. 2006 Jun;18(3):231-9. doi: 10.1016/ Epub 2006 May 2.


Eukaryotic DNA replication is a highly conserved process; the proteins and sequence of events that replicate animal genomes are remarkably similar to those that replicate yeast genomes. Moreover, the assembly of prereplication complexes at DNA replication origins ('DNA licensing') is regulated in all eukaryotes so that no origin fires more than once in a single cell cycle. And yet there are significant differences between species both in the selection of replication origins and in the way in which these origins are licensed to operate. Moreover, these differences impart advantages to multicellular animals and plants that facilitate their development, such as better control over endoreduplication, flexibility in origin selection, and discrimination between quiescent and proliferative states.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Cycle Proteins / metabolism
  • Cell Division
  • DNA Helicases / metabolism
  • DNA Replication*
  • Humans
  • Models, Genetic
  • Origin Recognition Complex / metabolism
  • Plants / genetics
  • Replication Origin


  • Cell Cycle Proteins
  • Origin Recognition Complex
  • DNA Helicases