Psychiatric morbidity is related to a chain of prenatal and perinatal adversities

Early Hum Dev. 2006 Nov;82(11):721-9. doi: 10.1016/j.earlhumdev.2006.03.003. Epub 2006 May 2.


Background: Most studies on the effects of early risk factors on future mental health focus on specific obstetric complications as risk factors for specific disorders. However, obstetric complications rarely occur in isolation, and the same holds for psychiatric problems.

Aims: To study prenatal and perinatal risk factors for psychiatric multimorbidity in early adulthood and to determine whether these differ from risk factors for monomorbidity.

Study design: Monomorbidity and multimorbidity of six types of psychiatric disorders were determined by a standardised psychiatric interview. Using univariate and multivariate logistic and ordinal logistic regression, associations of mono- and multimorbidity with prospectively collected early risk factors were examined.

Subjects: Two hundred and eighty-five young adults selected from a prospective birth cohort on the basis of their Obstetric Optimality Scores.

Outcome measures: Six types of psychiatric disorder and their co-occurrence.

Results: Monomorbidity was related to isolated early risk factors such as low birth weight or a low Apgar score, and to an accumulation of unfavourable pre- and perinatal events. Multimorbidity on the other hand, was only related to a chain of pre- and perinatal adversities.

Conclusion: Research and prevention strategies should not focus solely on isolated early risk factors, but also on the entire pre- and perinatal situation.

MeSH terms

  • Adult
  • Apgar Score
  • Birth Weight
  • Breast Feeding
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Infant, Newborn
  • Marital Status
  • Mental Disorders / epidemiology*
  • Mental Disorders / etiology*
  • Multivariate Analysis
  • Netherlands / epidemiology
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Prevalence
  • Risk Factors
  • Social Class