Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 56 (1), 53-5

Comparison of Sensititre YeastOne With the NCCLS M38-A Microdilution Method to Determine the Activity of Amphotericin B, Voriconazole, and Itraconazole Against Clinical Isolates of Aspergillus Fumigatus

Affiliations
Comparative Study

Comparison of Sensititre YeastOne With the NCCLS M38-A Microdilution Method to Determine the Activity of Amphotericin B, Voriconazole, and Itraconazole Against Clinical Isolates of Aspergillus Fumigatus

Jesús Guinea et al. Diagn Microbiol Infect Dis.

Abstract

The in vitro activities of amphotericin B, itraconazole, and voriconazole against 279 clinical isolates of Aspergillus fumigatus were studied by comparing Sensititre YeastOne with the reference method NCCLS (CLSI) M38-A. The methods were considered to agree when the results of the MICs by Sensititre were within 2 dilutions of the MICs obtained by NCCLS M38-A. Agreement of readings at 24, 48, and 72 h was as follows: amphotericin B (0%, 31.5%, 82.1%), itraconazole (86.7%, 98.3%, 98.2%), and voriconazole (92.8%, 98.3%, 98.9%). Sensititre YeastOne is a suitable alternative for the determination of the MICs of itraconazole and voriconazole against A. fumigatus when results are read at 48 h of incubation.

Similar articles

See all similar articles

Cited by 7 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback