Infection is still a major complication associated with surgery in orthopedics and traumatology. The implant design, the implant material, and the implantation technique may play essential roles in preventing infection. The goal of this paper is to discuss a series of experiments evaluating different aspects of both surgical procedures and implants. For this purpose, standardized local application of the human pathogen Staphylococcus aureus was performed in an animal model. Although these experimental results may be clinically relevant, direct extrapolation to clinical infection rates should be avoided.