Interferon-alpha treatment of molluscum contagiosum in a patient with hyperimmunoglobulin E syndrome

Pediatrics. 2006 Jun;117(6):e1253-1255. doi: 10.1542/peds.2005-2706. Epub 2006 May 1.


We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-alpha for 6 months without any adverse effect.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Child
  • Humans
  • Interferon-alpha / therapeutic use*
  • Job Syndrome / complications*
  • Male
  • Molluscum Contagiosum / drug therapy*
  • Molluscum Contagiosum / etiology*
  • Remission Induction


  • Antiviral Agents
  • Interferon-alpha