Antimicrobial C-glucoside from aerial parts of Diospyros nigra

Chem Pharm Bull (Tokyo). 2006 May;54(5):679-81. doi: 10.1248/cpb.54.679.

Abstract

A new C-alkylglucoside, diospyrodin [beta-1C-(1'S*,2'R*,3'R*,4'S*-1',2',3',4',5'-pentahydroxypentyl)-glucopyranoside] (1) has been isolated as its nonaacetate from the leaves and stems of Diospyros nigra. Its structure was elucidated on the basis of chemical and spectral properties and a single crystal X-ray analysis. It showed antimicrobial activity against Gram-positive and Gram-negative bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Diospyros / chemistry*
  • Glucosides / chemistry*
  • Glucosides / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Conformation
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Structure-Activity Relationship
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Glucosides
  • Plant Extracts
  • diospyrodin (beta-1C-(1'S*,2'R*,3'R*,4'S*-1',2',3',4',5'-pentahydroxypentyl)-glucopyranoside)